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. 2011 Feb 17;103(7):571–584. doi: 10.1093/jnci/djr029

Figure 1.

Figure 1

Safety and tissue levels of phenethyl isothiocyanate (PEITC) in wild-type (nontransgenic) male mice. A) Representative sections stained with hematoxylin and eosin of dorsal and lateral prostate from wild-type (nontransgenic) male mice fed either control diet or diet supplemented with 3 μmol PEITC/g for 19 weeks. Scale bar = 100 μm. B) Body weights over time of wild-type (nontransgenic) male mice fed control diet or diet supplemented with 3 μmol PEITC/g (n = 6 mice per group). Mean body weights with 95% confidence intervals (error bars) are shown. Statistical significance between control diet group and PEITC-supplemented diet groups was determined by two-sided mixed-effects analysis of variance (P = .11). C) Levels of PEITC in the plasma and prostate of wild-type (nontransgenic) male mice (n = 3 mice per group). P = .10 for both the plasma and the prostate between control and PEITC groups by Wilcoxon rank sum test. PEITC content below the lower limit of quantitation (asterisk). All statistical tests were two-sided.