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. Author manuscript; available in PMC: 2011 Apr 5.
Published in final edited form as: Adv Mater. 2010 Nov 9;22(42):4754–4758. doi: 10.1002/adma.201002767

Figure 2.

Figure 2

TSP-based DNA electrochemical sensor. a) The presence of target DNA is transduced to electrochemical signals by the specific binding of an avidin-HRP (horseradish peroxidase) conjugate to the biotin label of the reporter probe and the resultant catalyzed electro-reduction of hydrogen peroxide in the presence of an electroactive cosubstrate, TMB, which offers high enzyme-based signal amplification. b) Amperometric measurements in the presence of target DNA at 1 pM, 10 pM, 100 pM, 1 nM, and 5 nM with the sandwich mode. c) Comparison of TSP and ssDNA probe-based sensor performance with or without MCH passivation (with 1 nM target DNA).