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. 2011 Apr 5;5(4):e1012. doi: 10.1371/journal.pntd.0001012

Table 3. Inhibition parameters of Z-Phe-Ala-CHN2 and cathepsin K inhibitor II against recombinant F. hepatica cathepsin Ls.

Enzyme Inhibitor Ki(app) nM ± Ki nM ±
FhCL1 Z-Phe-Ala-CHN2 31.4 0.61 1.62 0.03
FhCL2 Z-Phe-Ala-CHN2 55.2 4.3 5.32 0.42
FhCL3 Z-Phe-Ala-CHN2 969.3 67.8 336.5 23.2
FhCL1 Cathepsin K inhibitor II 12.2 0.75 0.63 0.03
FhCL2 Cathepsin K inhibitor II 4.8 1.0 0.46 0.09
FhCL3 Cathepsin K inhibitor II 26.1 0.3 9.05 0.15