Table 1.
Daily dietary intake, morphological parameters, cardiac function and blood plasma metabolites from control (chow-fed) and high fat-fed rats
| Control (n = 6) | High fat-fed (n = 6) | |
|---|---|---|
| Dietary intake | ||
| Food intake (g/day) | 17.5 ± 1.7 | 20 ± 0.8 |
| Calorie intake (kcal/day) | 58 ± 6 | 102 ± 4**** |
| Morphological data | ||
| Body weight (g) | 415 ± 13 | 466 ± 17* |
| Heart weight (g) | 0.98 ± 0.03 | 1.08 ± 0.03* |
| HW/BW × 1,000 | 2.38 ± 0.05 | 2.34 ± 0.06 |
| Epididymal fat weight (g) | 11.4 ± 0.9 | 19.0 ± 1.8** |
| In vivo cardiac MRI | ||
| Left ventricle mass (g) | 0.45 ± 0.03 | 0.49 ± 0.04 |
| Septal wall thickness (mm) | 1.70 ± 0.06 | 1.75 ± 0.1 |
| Ejection fraction (%) | 77 ± 1 | 74 ± 1 |
| End-diastolic volume | 306 ± 23 | 307 ± 20 |
| End-systolic volume | 70 ± 6 | 79 ± 7 |
| Stroke volume (μl) | 236 ± 17 | 228 ± 16 |
| Heart rate (bpm) | 442 ± 9 | 473 ± 27 |
| Cardiac output (ml.min−1) | 104 ± 8 | 108 ± 10 |
| Fasting plasma metabolites | ||
| Glucose (mM) | 9.5 ± 0.7 | 11.2 ± 1.1 |
| Triglycerides (mM) | 1.6 ± 0.1 | 1.9 ± 0.2 |
| Free-fatty acids (mM) | 0.25 ± 0.03 | 0.38 ± 0.04* |
| Total cholesterol (mM) | 1.6 ± 0.1 | 2.0 ± 0.1* |
| LDL cholesterol (mM) | 0.04 ± 0.01 | 0.19 ± 0.02**** |
| HDL cholesterol (mM) | 0.65 ± 0.04 | 0.88 ± 0.11 |
* p < 0.05, ** p < 0.01, **** p < 0.0001 versus controls (HW/BW = heart weight/body weight)