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. 2011 Mar 10;150(2):196–203. doi: 10.1016/j.jconrel.2010.10.011

Fig. 2.

Fig. 2

Streptococcal protein G as a platform system for targeting E-selectin in vitro. (a) Diagram illustrating concept of retargeting pcAdluc by linking antibodies via protein G. Polymer coated virus shown in grey. (b) Retargeting protein G-pHPMA-coated adenovirus via E-selectin in rhTNF-α-activated HUVECs. Ad, unmodified adenovirus; StrepGpcAd, protein G-pHPMA-adenovirus; IgG-StrepGpcAd, isotype control-protein G-pHPMA-adenovirus; and MHES-StrepGpcAd, MHES-retargeted-protein G-pHPMA-adenovirus. Results are representative of three different experiments. Error bars are ± standard deviation. P values calculated using a one-way ANOVA (analysis of variance). *P < 0.05, **P < 0.01, and ***P < 0.001.