Skip to main content
. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: Thromb Haemost. 2009 Jul;102(1):35–41. doi: 10.1160/TH08-12-0818

Figure 2. Hybrid human/porcine fVIII molecules.

Figure 2

BDD fVIII molecules containing human (white) or porcine (gray) regions as single human domains or single porcine domains are shown. The linker region represents a short peptide containing a PACE/furin recognition sequence. FVIII domain boundaries are defined using human fVIII amino acid sequence numbering as follows: residues 1-372 (A1), 373-740 (A2), 1649-1689 (light chain activation peptide, ap), 1690-2019 (A3), 2020-2172 (C1) and 2173-2332 (C2) (36).