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The mechanosome network. Nucleocytoplasmic shuttling transcription factors cycle between the cytoplasm and nucleus. PTH- and/or load-induced deformation of the membrane launches adhesion-associated molecules from the adhesion complexes. The association of some of these adhesion proteins with the transcription factors for an armed “GO” mechanosome that drives bone formation. Other complexes form “STOP” mechanosomes that can attenuate “GO” mechanosome activity in the cytoplasm or nucleus
