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. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: Cancer Treat Res. 2010;156:11–24. doi: 10.1007/978-1-4419-6518-9_2

Fig. 2.1.

Fig. 2.1

Stages of murine folliculogenesis during in vitro follicle culture. All follicles shown are encapsulated within alginate. A two-layered secondary follicle (left) is the most immature follicle that can be cultured to obtain a live birth in vitro. A multilayer secondary follicle (center) and antral follicle (right) are the subsequent stages of folliculogenesis. Both two-layered and multilayered secondary follicles are referred to as pre-antral. The oocyte (Oo), granulosa cells (GC), and antrum(An) are labeled. Note that the oocyte is obscured in the antral follicle by the multiple layers of granulosa cells.