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Schematic of (KH)6-FGF2 fusion-protein mediated gene transfection. (i) Nucleic acid condensed by the positively charged fusion protein, (ii) vector recognition at the FGFR, (iii) internalization by receptor-mediated endocytosis , (iv) endosomal escape by proton-sponge mechanism, and (v) nuclear trafficking ensuing in transgene expression. Reprinted with permission from reference 114. Copyright 200- Elsevier.
