Table 1.

Summary of block chemistries, structures, morphologies, and potential applications of hybrid block copolymers with homopolypeptide blocks.

	A Block	B Block	Mw (number of units or kDa)	Morphologies	Secondary Structure	Solvent	Techniques	Size	Applications	References
1	poly(butadien)m	poly(L-lysine)n	m=107; n=200	spherical micelles	α-helix	aqueous solution	CD, DLS, SLS, TEM	82 ± 2 nm (low pH); 62± 2 nm (high pH)	Drug delivery	Gebhardt et al., 2007
			m=107; n=100	elongated micelles	coil	aqueous solution		226 ± 2 nm (low pH); 140 ± 2 nm (high pH)	Drug delivery	Gebhardt et al., 2007
			m=60; n=50	elongated micelles	coil	aqueous solution		155 ± 2 nm (low pH); 112 ± 2 nm (high pH)	Drug delivery	Gebhardt et al., 2007
2	poly(butadien)m (PB)	poly(L-lysine)n (P(Lys))	m=107; n=27	vesicles	α-helix/β-sheet	aqueous solution	CD, DLS, SLS, TEM	72 - 92 nm	Drug delivery	Gebhardt et al., 2008
3	poly(butadiene)m (PB)	b-poly(-L-glutamic acid)n (PGA)	m=40; n=100	polymersomes or peptosomes	α-helix	aqueous solution	SLS, DLS, fluorescence spectroscopy, TEM	100 - 150 nm	Drug delivery	Checot et al., 2003
4	poly(styrene)10 (PS)	b-(γ-benzyl-L-glutamate)n (Pblg)	n = 10 - 80	columnar hexagonal arrangement/lamellae (rod-coil architecture)	α-helix/β-sheet	THF	DSC, FTIR, SAXS, NMR	16 - 43 A	stimuli-sensitiv materials	Lecommandoux et al., 2001
5	poly(styrene)10 (PS)	b-(ε-benzyloxycarbonyl-L-lysine)r	n = 10 - 80	lamellae	α-helix/β-sheet	THF	DSC, FTIR, SAXS, NMR	20 A	stimuli-sensitiv materials	Lecommandoux et al., 2001
6	poly(tetrahydrofuran)m	b-poly(L-lysine)n	m=14; n=30; n = 18	vesicles and nanotubes	α-helix	aqueous solution	CD, DLA, TEM	80 - 117 nm	gene transfer therapy	Tian et al., 2008
7	PEG 750	b-poly(lysine)n	< 3.5 kDa	micelles	α-helix	DMF/water	NMR, XPS, FTIR, DLS, ESEM	120 - 150 nm	sutures, artificial tissues, implants and drug delivery	Deng et al., 2008