Table 2.

Summary of block chemistries, synthesis and properties of conjugated block copolymers with β-sheet forming sequences.

	A Block	B Block	Synthesis	Mw, kDa	Morphologies	Secondary Structure	Solvent	Techniques	Size
1	(PEG)3300	β-amiloid peptides: a) KLVFF	Fmoc solid phase synthesis	3.9	non-organized	random coil	methanol (0.25 %)	WAXS, SAXS, FTIR, AFM	N/A
		b) AAKLVFF		4.1	non-organized	random coil	methanol (0.25 %)		N/A
		c) FFKLVFF		4.2	fibrils	β -sheet	methanol (0.25 %)		H = 39 ± 17 nm; W = 56 ± 11 nm
2	(PEG)3000	de novo designed amphiphilic β-strand peptides (GKLKKLKQQELELELELG)	Fmoc solid phase synthesis	5	fibrillar rods	α-helix and β-strand	aqueous solution	CD, SAXS, TEM	nm scale
3	Cu2+, Zn2+, Ni2+	HPKFKIIEFEPPH	Fmoc solid phase synthesis	1.6	tape-like fibers	β -sheet	15 % ethanol/water (20mM Tris-HCl, pH7.4)	CD, TEM	nm scale
4	PEG	(A)4 and (A)6	Ring opening polymerization	15-25	nanostructures with hard and soft blocks	antiparallel β-sheets	40 % (w/v) HFIP	NMR, FTIR, AFM, X-ray diffraction	100-200 nm
5	PEO	GAGA	Step-growth polymerization	N/A	islands of a polypeptide-rich phase in a continuous polyether-rich	N/A	trifluoroethanol (TFE)	FTIR, X-Ray, 13C NMR, DSC, TEM, AFM	20-50 nm and 100-150 nm
6	polyferrocenylsilane (PFS)	GAGA	Fmoc solid phase synthesis	0.2	fibrous network	antiparallel β-sheets	toluene	NMR, FTIR, DCS, TEM	H = 3 - 5 nm; W = 22 - 50 nm
7	PEG	[(AG)3EG]10	Genetic Engineering	12	fibers	β-sheets and γ-turns	methanol	FTIR, AFM, TEM	H = 2 nm; W = 7.5-12 nm
8	PEG	β-amiloid peptide (YEVHHQKLVFFAEDVGSNKGAIIGL)	Fmoc solid phase synthesis	6.2	solid fibers	random coil to β-sheet transition	aqueous solution	NMR, CD, TEM	nm scale
9	poly(n-butyl acrylate) (pnBA)	(TV)5nFG	Fmoc solid phase synthesis	1.2 + pnBA	left-handed helical superstructures	antiparallel β-sheets	diethyl ether/methanol (85 %v/v)	CD, FTIR, AFM	H = 3 nm; W = 10 nm; P = 37nm