TABLE 2.
Univariate and multivariate predictors of overall survival
| Variable | Univariate Cox regression |
Multivariate Cox regression |
||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Age (continuous) | 1.02 (1.00–1.04) | <0.01 | 1.03 (1.01–1.05) | <0.01 |
| Gender | ||||
| Male | 1.26 (0.84–1.91) | 0.25 | 1.25 (0.81–1.94) | 0.30 |
| Preoperative stage | ||||
| I | 1 | |||
| II | 1.24 (0.48–3.17) | 0.64 | ||
| III | 2.08 (0.83–5.24) | 0.11 | ||
| Postoperative stage | ||||
| 0–I | 1 | 1 | ||
| II | 2.05 (1.17–3.58) | 0.01 | 1.80 (1.01–3.21) | 0.04 |
| III | 3.35 (2.06–5.44) | <0.01 | 2.87 (1.68–4.90) | <0.01 |
| Preoperative chemoradiation therapy | 0.91 (0.47–1.76) | 0.79 | 1.31 (0.62–2.75) | 0.47 |
| Postoperative chemotherapy | 1.04 (0.67–1.63) | 0.836 | 0.99 (0.61–1.60) | 0.98 |
| Multivisceral resection | 1.85 (1.12–3.04) | 0.01 | 1.40 (0.77–2.54) | 0.25 |
| Lymphovascular invasion | 1.94 (1.05–3.58) | 0.03 | 2.02 (0.99–4.10) | 0.05 |
| Perineural invasion | 3.67 (1.91–7.06) | <0.01 | 2.29 (1.13–4.64) | 0.02 |
| Type of surgery | ||||
| APR | 1 | 1 | ||
| CAA | 0.56 (0.37–0.85) | <0.01 | 0.57 (0.36–0.92) | 0.02 |
| Year of surgery | ||||
| 1992–1998 | 1 | 1 | ||
| 1999–2003 | 0.68 (0.43–1.07) | 0.09 | 0.54 (0.33–0.90) | 0.02 |
HR hazard ratio, CI confidence interval, APR abdominoperineal resection, CAA coloanal anastomosis