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. Author manuscript; available in PMC: 2011 Apr 6.
Published in final edited form as: Headache. 2009 Nov 17;50(4):588–599. doi: 10.1111/j.1526-4610.2009.01570.x

Table 1.

Characteristics of the 21 studies included according to MTHFR 677C>T and ACE D/I polymorphism

a) MTHFR 677C>T polymorphism
MTHFR 677C>T polymorphism
Total study size with genotypic information
(women, %)
Author, year Setting Ethnicity Study
design		 Gender controls any
migraine		 MA MO Comment
Kowa, 2000
(Japan)28 		NS Japanese case-control women+men 261
(67)		 74
(78)		 22
(68)		 52
(83)		 -----
Kara, 2003
(Turkey)26 		clinic Turkish case-control women+men 136
(88.2)		 93
(NS)		 23
(NS)		 70
(NS)		 Other gene variants investigated:
MTHFR 1298A>C
Lea, 2004
(Australia)29 		clinic Caucasian case-control women+men 269
(68)		 268
(68)		 168
(NS)		 100
(NS)		 -----
Oterino, 2005
(Spain)32 		clinic Caucasian case-control women+men 237
(61.6)		 329
(77.5)		 138
(76.8)		 191
(78.0)		 Study base from Oterino, 2004,31 but additional cases and controls.
Other gene variants investigated:
TS 2R/3R; MS 919D>G; MTHFD1 653R>Q
Scher, 2006
(Netherlands)34 		population mostly Caucasian cross-sectional women+men 1212
(44)		 413
(NS)		 187
(73)		 226
(76)		 -----
Todt, 2006
(Germany)36 		clinic Caucasian case-control NS 625
(NS)		 ----- 656
(NS)		 ----- -----
Kaunisto, 2006
(Finland)27 		clinic+population Caucasian case-control women+men 900
(75.6; 50.4)		 ----- 898
(81.7; 79.2)		 ----- Other gene variants investigated:
5 additional in MTHFR gene;
26 in ESR1 gene
Bottini, 2006
(Italy)25 		clinic Caucasian case-control women+men 66
(57)		 45
(60)		 33
(63.6)		 12
(50)		 Other gene variants investigated:
MTHFR 1298A>C;
PRT 20210G>A;
FVL 1698A>T
de Tommaso, 2007 (Italy)7 clinic Caucasian case-control women+men 97
(74)		 105
(77)		 ----- ----- -----
Pezzini, 2007
(Italy)8 		clinic Caucasian case-control women+men 105
(63.8)		 206
(NS)		 100
(68)		 106
(72.6)		 -----
Schürks, 2008
(US)9 		population Caucasian cross-sectional women 20424
(100)		 4577
(100)		 1275
(100)		 1951
(100)		 -----
Ferro, 2008
(Portugal)10 		clinic Caucasian case-control women+men 96
(NS)		 186
(82)		 78
(NS)		 108
(NS)		 Blood donor group chosen for control, because migraine was excluded.
Joshi, 2009
(India)11 		clinic North Indian case-control women+men, women, men 150
(67)		 150
(67)		 67
(76)		 83
(59)		 For MTHFR 677C>T the numbers of MA and MO cases do not match the numbers given earlier in paper.
Other gene variants investigated:
ACE D/I
Total number of subjects 24,578 6,446 3,645 2,899
b) ACE D/I polymorphism
ACE D/I polymorphism
Total study size with genotypic information
(women, %)
Author, year Setting Ethnicity Study
design		 Gender controls any
migraine		 MA MO Comment
Paterna, 2000 (Italy)16 clinic Caucasian case-control women+men 201
(63.2)		 ----- ----- 302
(66.2)		 New and larger sample of migraine patients, but same controls as in Paterna, 1997.33 Association of frequency and duration of migraine with ACE D/I also investigated.
Cakmak, 2003 (Turkey)17 NS Turkish case-control women+men, women, men 231
(NS)		 200
(NS)		 ----- ----- -----
Lin, 2005 (Taiwan)14 clinic Han Chinese case-control women+men, women, men 200
(70.5)		 240
(70.4)		 ----- ----- -----
Kowa, 2005 (Japan)15 NS Japanese case-control women+men 248
(69.4)		 176
(NS)		 54
(68.5)		 122
(84.4)		 -----
Lea, 2005 (Australia)13 NS Caucasian case-control women+men 244
(NS)		 250
(NS)		 151
(NS)		 99
(NS)		 Other gene variants investigated: MTHFR 677C>T; data are from Lea, 2004.29
Kara, 2007 (Turkey)12 NS Turkish case-control women+men 210
(85.7)		 180
(96.1)		 59
(96.7)		 109
(96.3)		 Other gene variants investigated: MMP-3
Tronvik, 2008 (Norway)19 clinic Caucasian case-control women+men 403
(57.8)		 347
(77.2)		 155
(NS)		 187
(NS)		 -----
Schürks, 2009 (US)18 population Caucasian cross-sectional women 20423
(100)		 4577
(100)		 1275
(100)		 1951
(100)		 -----
Joshi, 2009 (India)11 clinic North Indian case-control women+men, women, men 150
(67)		 150
(67)		 67
(76)		 83
(59)		 Other gene variants investigated: MTHFR 677C>T
Total number of subjects 22,310 6,120 1,761 2,853

NS: not specified.