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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Bioorg Med Chem. 2010 Oct 31;19(1):580–587. doi: 10.1016/j.bmc.2010.10.058

Scheme 5. Synthesis of HOHA-PC.

Scheme 5

Reagents and conditions: (a) porcine pancreatc lipase, phosphate buffer; (b) L-α-lysophosphatidylcholine (HO-PC), 2,6-dichlorobenzoyl chloride, 1-methylimidazole, CH2Cl2; (c) NaBH4, MeOH, (d) PPTS, THF/acetone/H2O (5:4:1).