Skip to main content
. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Bioorg Med Chem. 2010 Oct 31;19(1):580–587. doi: 10.1016/j.bmc.2010.10.058

Scheme 6. Syntheses of HOOA and HODA-PCs.

Scheme 6

Reagents and conditions: (a) oxalyl chloride, benzene; (b) PdCl2(MeCN)2 (1 mol%), DMF, 0 °C; (c) porcine pancreating lipase, PBS; (d) L-α-lysophosphatidylcholine (HO-PC), 2,6-dichlorobenzoyl chloride, 1-methylimidazole, CH2Cl2; (e) NaBH4, MeOH; (f) PPTS, THF/acetone/H2O (5:4:1)