Table 2. Genome-wide meta-analytic results for caffeine consumption (P<10−6).
| Index SNP | Chr | Position (NCBI 36) | Closest gene(s) (±100 kb) | Total SNPs* (P<1×10−3) | EA | EAF | Imputed and Genotyped | Genotyped | |||||
| N | β (SE) | P | P het ** | N | β (SE) | P | |||||||
| rs4410790 | 7 | 17251102 | AHR | 1 | T | 0.38 | 36013 | −0.15 (0.02) | 2.4×10−19 | 0.14 | 25738 | −0.16 (0.02) | 4.0×10−18 |
| rs2470893 | 15 | 72806502 | LMAN1L, EDC3, CYP1A2, CYP1A1, CSK | 1 | T | 0.31 | 47341 | 0.12 (0.02) | 5.2×10−14 | 0.68 | 25738 | 0.10 (0.02) | 9.5×10−8 |
| rs2472304 | 15 | 72831291 | CYP1A2 | 4 | A | 0.65 | 47325 | 0.08 (0.01) | 2.5×10−7 | 0.06 | 30663 | 0.07 (0.02) | 3.2×10−4 |
| rs6495122 | 15 | 72912698 | ULK3, SCAMP2, MP1, LMAN1L, CYP1A2, CSK, COX5A, CPLX3, C14orf17 | 1 | A | 0.43 | 47341 | −0.07 (0.01) | 5.8×10−7 | 0.08 | 25738 | −0.05 (0.02) | 0.007 |
| rs12148488 | 15 | 73169595 | SCAMP5,PPCDC | 3 | T | 0.50 | 47341 | −0.07 (0.01) | 5.9×10−7 | 0.43 | 25738 | −0.06 (0.02) | 0.001 |
Chr, chromosome; EA, effect allele; EAF, effect allele frequency; SE standard error.
*Number of significant SNPs in LD (r2 >0.5) and/or located <250 kb from index SNP according to HapMap.
**P value for between study heterogeneity.