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. 2011 Mar 22;4(3):315–321.

Figure 2.

Figure 2

(a)Primary melanoma, shave biopsy: confluent irregular nests within the dermis and as single units at the dermo-epidermal junction (H&E, ×4); (b) Close-up of Figure 2a. No clear cells or melanin pigment was identified (H&E, ×40); (c). Primary melanoma, wide and deep excision: note the minimal amount of balloon cells in a background of predominantly “basaloid” and spindle-shaped melanoma cells. The balloon cells occupy less than 50% of the tumor (H&E, 4×); (d) Primary melanoma, wide and deep excision: the polyhedral balloon cells are arranged in nests and cords separated by thin fibrous septae. They show discernabie cytopiasmic membranes and foamy to clear cytoplasm with occasional pale eosinophilic granules. They are minimally pleomorphic, variably sized, ranging from 40-100 microns in diameter, and show a central or eccentric nuclei. Few prominent nucleoi are seen (H&E, 40×); (e) Primary melanoma, wide and deep excision: intraepidermal pagetoid spread is present. Note the presence of a mitotic figure in the spindle-shaped population of melanoma cells. Hemosiderin is observed (H&E, 40×); (f) Metastatic balloon cell malignant melanoma (BCMM), fine-needle aspiration: sheets of discohesive, large, polyhedral foamy cells with granular cytoplasm. Cytopiasmic membranes are indistinct. These cells show bland nuclear features with a low nuclear to cytopiasmic ratio. Eccentrically placed nuclei are round to ovoid. Occasional intranuclear cytopiasmic inclusions and inconspicuous nucleoli are identified. No pigmentation is present (Pap, 40×); (g) Metastatic BCMM. The lymph node shows near complete replacement by balloon melanoma cells. No spindle-shaped or epithelioid melanoma cells are present H&E, 4×); (h) Metastatic BCMM. The balloon melanoma cells are arranged in nests separated by thin fibrous septae and are histologically identical to those seen in the primary lesion (H&E, 10×); (i) Metastatic BCMM. The tumor shows mild pleomorphism with focal areas of high cellular-ity and nuclear pleomorphism (H&E, 60×); (j) Metastatic BCMM. The majority of the tumor is cytologically bland with minimal pleomorphism (H&E, 60×).