Figure 5.

Impaired contractility in CypherL KO mouse hearts. (A and B) WT and CypherL KO mice had comparable heart rates and left ventricle systolic blood pressure at the age of 5 months. (C) CypherL KO mice had significantly reduced maximum dP/dt under 4 ug/kg/min of dobutamine stimulation. (D) CypherL KO mice have reduced minimum dP/dt both at basal condition and with various doses of dobutamine perfusion. (E) Tau was larger in CypherL KO mice under 0.75 or 2 μg/kg/min of dobutamine stimulation than WT control mice (*P< 0.05).