Figure 3.

Overexpression of mIGF-1 modestly improves survival of SMA mice. (A) Kaplan–Meier survival curves comparing mIGF-1^NEG and mIGF-1^POS SMA mice. Median survival in mIGF-1^NEG SMA mice was 10 days and median survival in mIGF-1^POS mice was 14 days (log-rank P = 0.025, n = 52 mIGF-1^NEG and n = 33 mIGF-1^POS SMA mice). (B) Body weight was increased in SMA mIGF-1^POS mice on P7, P8 and P9 compared with SMA mIGF-1^NEG mice (*P < 0.05 and **P < 0.01, as determined by multiple imputation test). (C) Average righting time showed no difference between SMA mIGF-1^NEG and mIGF-1^POS mice (n = 52 and n = 33, respectively). (D) The composite tube test score also did not show statistically significant differences between mIGF-1^NEG and mIGF-1^POS SMA mice (n = 8 mice per group). Values represent average ± SEM.