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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: J Immunol. 2010 Nov 8;185(12):7596–7604. doi: 10.4049/jimmunol.1002846

FIGURE 5.

FIGURE 5

SP-mediated protection from HIV infection correlates closely with SP-mediated reductions in CD4+ T cell expression of CD4 and CD38 as well as CD4+ T cell proliferation. The magnitude of the reduction in CD4+ T cell infection by HIV IIIB correlated positively with the magnitude of the SP-mediated reduction in CD4+ T cell MFI of the HIVR CD4 (A), the MFI of the activation marker CD38 (B), and with the reduction in CD4+ T cell proliferation (C) by CFSE staining. Likewise, the magnitude of the reduction in CD4+ T cell infection by HIV BaL correlated positively with the magnitude of the SP-mediated reduction in CD4+ T cell CD4 MFI (D), CD4+ T cell CD38 MFI (E), and CD4+ T cell proliferation (F). SP contains multiple cytokines and chemokines (G). n = 20 for A–G.