Effect of duration of abstinence from methamphetamine (MA) on Brief Symptom Inventory (BSI) scores (n = 25), compared to healthy control (HC) subject sample (n = 85). Data represent mean BSI subscale score at each time-point (0: study entry; 1–5: represents data collected at end of each week of hospitalization indicated); error bars represent standard deviation of each value. *P < 0.05 MA versus HC sample at time-point: **P < 0.001 MA versus HC sample at time-point. #P < 0.05 MA subjects: time-point versus study entry, ##P < 0.01 MA subjects: time-point versus study entry. (A) Depression subscale: effect of duration of abstinence, P = 0.001. (B) Psychoticism subscale: effect of duration of abstinence, P = 0.003. (C) Obsession subscale: effect of duration of abstinence, P < 0.001. (D) Anxiety subscale: effect of duration of abstinence, P < 0.001. (E) Additional symptoms subscale: effect of duration in abstinence, P = 0.131. (F) Interpersonal sensitivity subscale: effect of duration of abstinence, P < 0.001. (G) Paranoia subscale: effect of duration of abstinence, P = 0.003. (H) Phobia subscale: effect of duration of abstinence, P = 0.506. (I) Hostility subscale: effect of duration of abstinence, P < 0.001. (J) Somatization subscale: effect of duration of abstinence, P < 0.001. (K) Global symptoms index (GSI) subscale: effect of duration of abstinence, P < 0.001