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FOXO transcription factors need DNA contact to induce transcription of target genes, and the activity is primarily dependent on subcellular location. AKT dependent phosphorylation mediates export from the nucleus, while AMPK phosphorylation on other amino acid residues activates transcription. Acetylation inactivates FOXO transcription, while deacetylation by sirt1 and sirt3 has the opposite effect.
