Table 1. SIV-infected, CD8+ T Lymphocyte depleted animals used in this study.
Animal no. | Minocycline | Length of infection (days) | CD8+ lymphocyte depletiona | Terminal plasma viral load (copy eq. /mL)b |
74 – 05 | None | 56 | Persistently depleted | 5.6×107 |
79 - 05 | None | 42* | Persistently depleted | 6.3×107 |
156 - 04 | None | 62 | Persistently depleted | 3.6×108 |
346 - 04 | None | 62 | Persistently depleted | 6.2×108 |
307 - 05 | None | 43* | Persistently depleted | 6.5×107 |
118 - 07 | None | 57 | Persistently depleted | 1.8×108 |
121 - 07 | None | 57 | Persistently depleted | 2.2×108 |
94 - 04 | Started 28 dpi | 60 | Persistently depleted | 9.0×106 |
35 - 07 | Started 28 dpi | 62 | Persistently depleted | 8.0×107 |
150 - 04 | Started 28 dpi | 60 | Persistently depleted | 8.3×107 |
150 - 05 | Started 28 dpi | 55 | Persistently depleted | 6.3×107 |
48 - 07 | Started 28 dpi | 62 | Transiently depleted | 4.3×106 |
227 - 04 | Started 28 dpi | 60 | Transiently depleted | 8.9×106 |
258 - 04 | Started 28 dpi | 62 | Transiently depleted | 2.7×107 |
Note.-dpi = days post infection.
*Untreated animals time-sacrificed at 6 weeks pi; all other animals sacrificed at 8 weeks pi.
Transiently CD8+ lymphocyte depleted (≤21 dpi), persistently CD8+ lymphocyte depleted (>28 dpi).
Viral RNA quantitiated using RT PCR and are results of duplicate measurements.