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. 2011 Apr 6;6(4):e18568. doi: 10.1371/journal.pone.0018568

Figure 5. Behavioral analysis of LRRK2 transgenic mice.

Figure 5

A–D, In the open field G2019S LRRK2 TG mice (line 340) exhibit normal horizontal (A) and vertical (B) locomotor activity compared to NTG littermates at 6 and 15 months (n = 7–9 mice/genotype). R1441C LRRK2 TG mice (line 574) reveal normal locomotor activity at 6 months but deficits at 15 months (C and D) compared to NTG mice (n = 6-9 mice/genotype). Data represent the number of beam breaks during the first 15 min period. E–F, Normal pre-pulse inhibition (PPI) of the acoustic startle response in LRRK2 transgenic mice. E and F, G2019S and R1441C LRRK2 TG mice display normal PPI of the acoustic startle reflex at 15 months compared to their NTG littermates, with increasing pre-pulse tones of 74–90 dB (n = 6–8 mice/genotype). Data are expressed as % PPI relative to no pre-pulse tone. Bars present the mean ± SEM. *P<0.05 comparing TG with NTG as indicated.