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. Author manuscript; available in PMC: 2012 Apr 13.
Published in final edited form as: J Agric Food Chem. 2010 Jul 21;59(7):2808–2815. doi: 10.1021/jf101747r

Figure 3. Blockade of MAGL and FAAH by OP and TC pesticides alters brain endocannabinoid levels and elicits catalepsy.

Figure 3

A.The endocannabinoid system has two endogenous ligands, 2-AG and anandamide, which are degraded by MAGL and FAAH, respectively, to terminate their action on the CB1 receptor. B. Brain 2-AG, anandamide and arachidonic acid levels of mice treated with 9 OP and TC pesticides. C. Degree of catalepsy, scored as seconds that a mouse is unresponsive on a bar during a 60 second period. Data represent n=3 mice group, with significance expressed as **p<0.01 compared to control. Data are given as mean ± standard error.