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. Author manuscript; available in PMC: 2012 Apr 13.
Published in final edited form as: J Am Chem Soc. 2011 Mar 18;133(14):5240–5243. doi: 10.1021/ja2011109

Figure 4.

Figure 4

Extracted ion chromatograms showing production of pacidamycin analogs using 5’-aminouridine as an offloading substrate. The calculated mass with 10-ppm mass error tolerance was used. The assay components are shown in Table S2; the HR-MS and HR-MS/MS analyses of each compound are shown in Figure S6–8. The MS/MS fragments confirmed the attachment of uridine moiety to DABA3 carbonyl through an amide linkage, as well as the regiospecific modifications of DABA3 amino (Nα vs. Nβ).