LIPN Expression Analysis
(A) Quantitative RT-PCR was performed on mRNA samples extracted from keratinocyte cultures derived from a patient and a nonaffected individual (control). Results are provided as a percentage of LIPN expression in control keratinocytes ± SD.
(B) LIPN expression was assessed via Clontech tissue blot cDNA array. Expression of LIPN was normalized to that of ACTB. Results are provided as a percentage of LIPN expression in control keratinocytes ± SD. The following abbreviations are used: ESON = esophagus; S.INT = small intestine; PLACEN = placenta; TRACH = trachea; PROST = prostate; KC = keratinocytes.
(C) Total RNA was extracted from organotypic cell cultures at day 0 (green), day 7 (blue), and day 10 (red). LIPN, IVL, and KRT10 expression were compared by using quantitative RT-PCR. Results are provided as a percentage of expression at day 0.