Figure 3.

Comparison of the WAS of Four Disjoint Sets of Mutations from the Cosmic Database and the WAS of HumVar Neutral Mutations

The five sets consist, respectively, of the neutral mutations in HumVar, the mutations appearing in only one sample (1), those appearing in two to four samples (2–4), those appearing in five to nine samples (5–9), and those appearing in ten or more samples (10+) in the Cosmic database. The points represent the mean WAS; the error bars represent the standard error of the mean. The weights were computed from the HumVar dataset. The p values resulting from the Wilcoxon-Mann-Whitney test of each group-group comparison are shown in the graph. (All comparisons including neutral polymorphisms yielded p values smaller than 10⁻³¹⁸.)