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. 2011 Apr 8;88(4):440–449. doi: 10.1016/j.ajhg.2011.03.004

Figure 5.

Figure 5

Mutational Landscape of the C-Terminal Half of the DNA-Binding Domain of p53

The abscissa of all graphs represents the position within the sequence. The bottom graph depicts the mean WAS of mutants at each position, and the other four graphs contain the mean biological activity, measured as the trans-activation of transcription at four yeast promoters (WAF1, MDM2, AIP1, and NOXA, from top to bottom). Only 0.5% of the neutral mutations in HumVar score at or above the WAS value marked by the red line in the bottom graph; vertical broken lines show the positions with mean WAS greater than this value.