Fig. 3.

Efficacy of tocilizumab infusion in inhibiting the signs and symptoms of RA patients seen in daily clinical practice. Disease activity as assessed by DAS28 values at baseline and after 24 weeks of tocilizumab therapy is shown: a all 229 cases, b patients who concomitantly received MTX (n = 127), c patients who did not concomitantly receive MTX (n = 102), d patients who previously received anti-TNF therapy (n = 144), e patients who did not previously receive anti-TNF therapy (n = 85). Disease activity was categorized as high (DAS28 > 5.1), moderate (3.2 ≤ DAS28 ≤ 5.1), low (2.6 ≤ DAS28 < 3.2) and remission (DAS28 < 2.6) from the top column. Data were analyzed by the LOCF method