Table 2.

Laboratory data at baseline and 24 weeks

Laboratory tests	Week	All cases				Concomitant methotrexate								Prior use of anti-TNF
						With MTX				Without MTX				With anti-TNF				Without anti-TNF
		n	Mean	SD	P	n	Mean	SD	P	n	Mean	SD	P	n	Mean	SD	P	n	Mean	SD	P
WBC (/mm3)	0	208	7,707.2	2,701.3	<0.0001	111	7,557.7	2438.6	<0.0001	97	7,878.4	2977.5	<0.0001	132	7,697.0	2,558.6	<0.0001	76	7,725.0	2,950.4	0.00033
	24	208	6,270.2	2,649.5		111	5,969.4	2693.2		97	6,614.4	2569.3		132	6,122.7	2,567.2		76	6,532.3	2,785.4
Hb (g/dl)	0	206	11.1	1.7	<0.0001	111	11.3	1.7	<0.0001	95	10.9	1.7	<0.0001	131	11.2	1.6	<0.0001	75	11.0	1.8	<0.0001
	24	206	12.0	1.9		111	12.3	1.8		95	11.7	1.9		131	12.2	1.9		75	11.8	1.8
AST (IU/l)	0	211	22.7	14.3	<0.0001	113	21.2	8.2	<0.0001	98	24.4	18.9	0.2183274	134	23.3	17.0	0.00821	77	21.7	7.6	<0.0001
	24	211	27.5	13.9		113	28.1	14.0		98	26.7	13.9		134	27.5	15.6		77	27.3	10.3
ALT (IU/l)	0	211	18.5	15.0	<0.0001	113	18.1	9.9	<0.0001	98	18.9	19.3	0.1307027	134	19.6	17.1	0.00324	77	16.5	10.0	<0.0001
	24	211	26.1	24.4		113	29.6	28.8		98	22.2	17.5		134	27.3	27.9		77	24.1	16.7
TC (mg/dl)	0	166	189.0	38.2	<0.0001	86	188.8	35.7	<0.0001	80	189.1	41.0	<0.0001	98	190.4	37.8	<0.0001	68	186.8	39.0	<0.0001
	24	166	204.3	39.7		86	206.5	32.7		80	202.0	46.1		98	206.5	37.7		68	201.2	42.4
ESR (mm/1 h)	0	227	62.6	29.8	<0.0001	126	61.4	28.5	<0.0001	101	64.1	31.4	<0.0001	143	62.1	28.5	<0.0001	84	63.5	32.1	<0.0001
	24	227	24.2	28.1		126	19.6	25.2		101	29.9	30.4		143	23.4	26.9		84	25.5	30.1
CRP (mg/dl)	0	227	3.2	3.0	<0.0001	127	3.2	2.8	<0.0001	100	3.1	3.3	<0.0001	143	3.2	3.0	<0.0001	84	3.1	3.0	<0.0001
	24	227	0.9	2.1		127	0.8	1.8		100	1.1	2.5		143	0.9	1.9		84	1.0	2.4
MMP-3 (ng/ml)	0	190	332.9	366.2	<0.0001	98	346.0	434.5	<0.0001	92	319.0	277.4	<0.0001	119	342.8	307.8	<0.0001	71	317.5	449.4	0.00148
	24	190	195.7	289.9		98	191.1	363.0		92	200.5	184.6		119	180.3	180.3		71	226.0	413.1

P value between 0 week and 24 weeks

WBC White blood cells, Hb hemoglobin, AST aspartate aminotransferase, ALT alanine aminotransferase, TC total cholesterol, MMP-3 matrix metalloproteinase-3