Fig. 1.

The effects of genetic deficiency of Ar on the pathohistological development of DN in the renal cortex and glomerulus as determined by PAS staining. a Renal cortex and glomerulus morphology in six treatment groups of mice at the age of 25 weeks as determined by PAS staining. The results were typical of three mice for each treatment group. Original magnification ×1,000; scale bar, 25 μm. b Quantitative analyses of ECM accumulation index in six treatment groups of mice. Values were expressed as the mean ± SEM, n = 3; *p < 0.05, **p < 0.01. c Quantitative analyses of glomerular sizes in six treatment groups of mice. Glomerular area was determined as described in the Methods. Values are expressed as the mean ± SEM, n = 3; *p < 0.05, **p < 0.01, ***p < 0.001