Loss of Il1rap in Sharpincpdm/Sharpincpdm mutant mice resulted in mice appearing clinically normal (A, C) compared to Il1rap+/+, Sharpincpdm/Sharpincpdm mutant mice (B, D). Histology revealed decreased severity of the skin lesions but not total resolution of diseases as shown by epidermal thickness (E;1 represents +/+, Sharpincpdm/Sharpincpdm; 2 represents l1raptm1Roml/Il1raptm1Roml, Sharpincpdm/Sharpincpdm; 3 represents l1raptm1Roml/Il1raptm1Roml, +/+; and 4 represents +/+, +/+). Note: size of PCR products: Il1rap band (168bp), Neo (280bp). Bar = 5 um.