Table 1.
Troponin T Group | ||||||
---|---|---|---|---|---|---|
Group 1 (<0.003 μg/L) (n=3258) | Group 2 (0.003 μg/L to ≤0.005 μg/L) (n=2500) | Group 3 (0.006 μg/L to ≤0.008 μg/L) (n=1971) | Group 4 (0.009 μg/L to ≤0.013 μg/L) (n=1254) | Group 5 ≥0.014 μg/L (n=715) | P | |
Demographic | ||||||
• Age, yrs | 60.7 | 62.4 | 63.6 | 64.9 | 65.2 | <0.0001 |
• Race, % white | 78.2 | 80.7 | 78.2 | 76.6 | 70.4 | <0.0001 |
• Gender, % male | 20.9 | 37.7 | 52.8 | 63.6 | 73.7 | <0.0001 |
• BMI, kg/m2 | 27.8 | 28.6 | 29.4 | 30.0 | 30.4 | <0.0001 |
Medical History | ||||||
• Hypertension, % | 38.7 | 42. | 48.2 | 53.6 | 61.9 | <0.0001 |
• Current smoking, % | 22.0 | 13.0 | 10.0 | 10.0 | 11.2 | <0.0001 |
• Former smoking, % | 40.5 | 42.2 | 42.6 | 43.8 | 43.7 | 0.297 |
• Diabetes mellitus, % | 9.8 | 12.4 | 17.3 | 21.1 | 35.4 | <0.0001 |
• Systolic blood pressure, mm Hg | 125.2 | 126.6 | 128.1 | 130.5 | 130.8 | <0.0001 |
• Diastolic blood pressure, mm Hg | 70.7 | 71.1 | 71.5 | 71.9 | 70.9 | 0.0088 |
Laboratory Data | ||||||
• Total cholesterol, mg/dL | 203.6 | 202.1 | 201.1 | 200.6 | 197.3 | 0.0027 |
• HDL-C, mg/dL | 51.8 | 51.0 | 50.2 | 49.6 | 48.7 | <0.0001 |
• Triglycerides, mg/dL | 137.8 | 139.1 | 142.8 | 149.5 | 157.1 | 0.0002 |
• eGFR, mL/min† | 86.6 | 85.6 | 84.0 | 82.5 | 76.8 | <0.0001 |
• Mean hs-CRP, mg/L‡ | 4.2 | 4.2 | 4.3 | 4.5 | 6.9 | <0.0001 |
• Mean NT-proBNP, pg/mL§ | 70.1 | 92.4 | 112.4 | 149.9 | 530.7 | <0.0001 |
Medications | ||||||
• Aspirin, % | 53.9 | 53.8 | 53.3 | 54.9 | 57.9 | 0.310 |
• Antihypertensives, % | 27.8 | 30.8 | 37.0 | 41.3 | 50.6 | <0.0001 |
• Statins, % | 8.8 | 8.2 | 7.9 | 9.9 | 10.4 | 0.143 |
LVH, %|| | 1.8 | 2.0 | 3.3 | 4.2 | 8.2 | <0.0001 |
Adjusted for age, gender, and race
eGFR calculated with the Chronic Kidney Disease Epidemiology Collaboration formula
Unadjusted median hs-CRP (mg/L): Group 1, 2.68; Group 2, 2.30; Group 3, 2.14; Group 4, 2.10; Group 5, 2.74; p<0.0001
Unadjusted median NT-proBNP (pg/mL): Group 1, 59.00; Group 2, 61.65; Group 3, 61.60 Group 4, 71.30; Group 5, 98.00; p<0.0001
LVH calculated by electrocardiographic Cornell Criteria