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. Author manuscript; available in PMC: 2011 Sep 17.
Published in final edited form as: Nature. 2011 Mar 2;471(7338):373–376. doi: 10.1038/nature09878

Figure 2. FADD deficiency partially corrects the RIP1−/− T cell developmental defect by blocking apoptosis.

Figure 2

Lymphocytes (a-b) in the chimeras of the indicated genotypes were analyzed. E18.5 fetal thymocytes of the indicated genotypes were treated with anti-Fas antibodies (c) or TNFα (d) and death responses determined 12 hours post stimulation. Error bars represent mean ± SEM of triplicates. T cells (e) and B cells (f) from NSG chimeras of the indicated genotypes were stimulated with anti-CD3 and anti-CD28 antibodies or with LPS, respectively. MEFs were stimulated with TNFα (g). NF-κB activation was indicated by the induction of p65 phosphorylation. β-actin, loading controls.