Table 1.
| |||||
---|---|---|---|---|---|
Compound | R1 | R2 | R3 | R4 | IC50 (μM) |
1 | CH3 | OCH3 | (2,6-DiMeO)Ph | 4-OCH3 | 0.0060 |
2 | CH3 | H | (2,6-DiMeO)Ph | 4-OCH3 | 0.017 |
3 | CH3 | OCH3 | (2,6-DiMeO)Ph | 3-CONH2 | 0.020 |
4 | CH3 | H | (2,6-DiMeO)Ph | 3-CONH2 | 0.030 |
5 | CH3 | OCH3 | Ph | 3-CONH2 | 0.050 |
6 | CH3 | OCH3 | 4-ClPh | 3-CONH2 | 0.12 |
7 | CH3 | OCH3 | Ph | 3-CH2OCH3 | 0.30 |
8 | CH3 | H | (2,6-DiMeO)Ph | 3-CH3 | 0.50 |
9 | CH3 | H | (2,6-DiMeO)Ph | 3-CN | 0.60 |
10 | CH3 | H | Ph | 3-CONH2 | 1.1 |
11 | CH3 | H | Ph | 3-CN | 2.2 |