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. Author manuscript; available in PMC: 2011 Dec 15.
Published in final edited form as: Cancer Res. 2010 Nov 5;70(24):10371–10380. doi: 10.1158/0008-5472.CAN-10-1354

Figure 6. Six1 mediates the switch in TGF-β signaling from tumor suppressive to tumor promotional.

Figure 6

In early stage lesions, TGF-β signaling acts as a tumor suppressor blocking tumor development and suppression. However as the tumor progresses, Six1 overexpression leads to increased TGF-β signaling through upregulation of TβRI. In addition, Six1 switches the function of TGF-β from tumor suppressive to pro-metastastic, facilitating the dissemination of the tumor cells from the primary tumor to secondary sites.