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. 2011 Mar 8;2:227. doi: 10.1038/ncomms1237

Figure 2. Detailed interactions between the CFP1 CXXC domain and the GCGG double-stranded DNA (5′-GCCAGCGGTGGC-3′).

Figure 2

(a) Stereo view of the interactions of the CFP1 CXXC domain with nucleotides outside the CpG motif. The DNA molecule and protein are coloured in salmon and grey cartoon representations, respectively. Residues or nucleotides involved in interactions are coloured in cyan sticks (CFP1) and salmon sticks (DNA). (b) CpG-specific interactions. The DNA molecule and CFP1 are coloured in salmon and grey cartoon representations, respectively. Residues or nucleotides involved in interactions are coloured in cyan sticks (CFP1) and salmon sticks (CpG). (c) Schematic representation of the CFP1 CXXC domain and the CpG–DNA complex. Hydrogen bonds, including those mediated by water, are marked by red arrows.