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. 2011 Mar 30;52(4):2065–2085. doi: 10.1167/iovs.10-6997h

Table 5.

List and Frequency of Reported Criteria (All Studies Represented)

A. Inclusion Criteria Frequency (%)
Age of Participants
Adult patients 22/26 (84.6)
Pediatric patients 2/26 (2.7)
Adult and pediatric patients 1/26 (3.8)
Not mentioned 1/26 (3.8)
Symptomatology
Ocular Surface Disease Index questionnaire 1/26 (3.8)
Symptoms fail to improve with conventional therapy 3/26 (11.5)
Discomfort or foreign body sensation 2/26 (7.7)
Eye redness 1/26 (3.8)
Photophobia 1/26 (3.8)
Ocular dryness 3/26 (11.5)
Contact lens intolerance 1/26 (3.8)
Ocular Symptoms Scale 1/26 (3.8)
Lid Margin Findings
Previous or current diagnosis of MGD or posterior blepharitis 12/26 (46.1)
Posterior lid margin erythema or hyperemia 5/26 (19.2)
Eyelid edema 1/26 (3.8)
Lid margin thickening or irregularity 4/26 (15.4)
Meibomian gland orifice plugging 8/26 (30.8)
Cloudy, yellow, or frothy meibomian gland secretions 5/26 (19.2)
Lid margin telangiectasia 4/26 (15.4)
Meibomian gland capping 3/26 (11.5)
Meibomian gland loss/destruction 5/26 (19.2)
Chalazia 1/26 (3.8)
Eyelid inflammation (not defined) 2/26 (7.7)
Eyelid noninflammation 2/26 (7.7)
Ocular Surface Findings
Rosacea-associated eyelid and corneal changes 3/26 (11.5)
Tear Film Findings
Tear interferometry 1/26 (3.8)
TBUT<10 seconds 1/26 (3.8)
TBUT<5 seconds 1/26 (3.8)
Schirmer's test <10 seconds 1/26 (3.8)
Existing Classification Scheme
McCulley Classification system for MGD27 2/26 (7.7)
B. Exclusion criteria1,2,68,10,12,1421,24,26 Frequency (%)
Contact lenses use 10/17 (58.8)
History of ocular surgery 7/17 (41.2)
Eye disorders affecting the ocular surface 6/17 (35.3)
Meibomitis, seborrheic MGD, and excessive meibomian lipid secretion 4/17 (27.5)
Topical medical therapy (of any kind) 4/17 (27.5)
Infectious conjunctivitis 4/17 (27.5)
Systemic diseases affecting the ocular surface 4/17 (27.5)
Topical or systemic steroids use 3/17 (17.6)
Active ocular disease 3/17 (17.6)
Pregnancy or childbearing age without contraception 3/17 (17.6)
Stevens-Johnson syndrome 3/17 (17.6)
Chemical, thermal, or radiation injury 3/17 (17.6)
Decreased reflex tearing (<10 mm/5 min Schirmer test result) 2/17 (11.8)
Diabetes 2/17 (11.8)
Current treatment for blepharitis 2/17 (11.8)
Topical or systemic antibiotics 2/17 (11.8)
Alteration of lacrimal drainage system 2/17 (11.8)
Drugs affecting tearing 2/17 (11.8)
Sjögren's syndrome 2/17 (11.8)
MGD with acute inflammation 2/17 (11.8)
Anterior blepharitis with more than moderate severity 2/17 (11.8)
Active ocular allergy 2/17 (11.8)
Inflammatory diseases unrelated to MGD 2/17 (11.8)
Ocular adnexal pathology interfering with warm compress application 2/17 (11.8)
Lid structural abnormality 2/17 (11.8)
Topical or systemic antimetabolites 1/17 (5.9)
Eyelid surgery 1/17 (5.9)
Use of isotretinoin within the past 6 months 1/17 (5.9)
Autoimmune disease requiring treatment 1/17 (5.9)
Smokers 1/17 (5.9)
Punctal plugs 1/17 (5.9)
Anterior chamber inflammation 1/17 (5.9)
Glaucoma 1/17 (5.9)
Anterior segment diseases 1/17 (5.9)
Best corrected visual acuity <1.0 logMAR 1/17 (5.9)
Lid skin disease 1/17 (5.9)
Cicatricial conjunctival diseases 1/17 (5.9)
Sensitivity to study medication 1/17 (5.9)