Fig. 2.

a Two-dimensional ultrasound echography in the 30th week of pregnancy in case 2. The sonogram displays a flat profile with exophthalmos-like structures. b Ultrasound examination in the 30th week of pregnancy in case 2. The 3-dimensional picture reconstructed from the 2-dimensional pictures shows abnormal structures on the eyes. c External photograph of case 2 with HI immediately after birth. The skin over the whole body is thickened with a number of fissures and rashes, a face without mimicry, nasal hypoplasia, and a fixed and open mouth. Both eyes display extreme conjunctival protrusion associated with severe chemosis preventing the observation on the eyes. d External photograph of case 2 with HI immediately after birth. The protruding conjunctivae are improved with a decrease in the tension of the periocular skin. The facial skin was kept moist by a sterile gauze with holes for eyes and nose. e External photograph of both eyes of case 2 with HI 19 days after birth. The conjunctival protrusion was prominent when the infant held her breath. The protruding mucosal tissue was identified as superior bulbar conjunctiva because the palpebral conjunctiva can be seen. f External photograph of both eyes of case 2 with HI 3 months after birth. The ectropion has greatly improved with a decrease in the tension of the periocular skin.