Fig. 3.

Effects of M100907 pretreatment on cue-elicited reinstatement of extinguished cocaine-seeking behavior when injected directly into the vmPFC, expressed as mean responses/hour ± SEM on the active lever. Animals assigned to receive 0.1 (n=13), 0.3 (n=12), 1.0 (n= 14), or 1.5 (n=17) μg/0.2 μl/side M100907 into the vmPFC were tested on 1 day with their assigned dose (striped bar) and on another day with the vehicle (black bar), with order counterbalanced. These pretreatments were infused within 1 min before placing the animals into the self-administration chambers, where light and tone cues were available response-contingently on an FR1 schedule. Baselines (white bar) were calculated as the average number of active lever presses during the extinction sessions immediately preceding each test. The asterisk (*) represents a significant difference from extinction baseline, test of simple main effects, P<0.05. The plus sign (+) represents a significant difference from vehicle pretreatment session, planned t tests, P<0.05