Fig. 6.

Effects of M100907 priming injections on reinstatement of extinguished cocaine-seeking behavior, expressed as mean responses/hour ± SEM on the active lever. Animals received 0.1 (n=13), 0.3 (n= 13), 1.0 (n=14), or 1.5 (n=13) μg/0.2 μl/side M100907 infused into the vmPFC on one test day (striped bar) and vehicle on another day (black bar), with order counterbalanced. They were placed into the self-administration chambers immediately after these pretreatments. Baselines (white bar) were calculated as the average number of active lever presses obtained during the extinction sessions immediately preceding each test. No cues were presented during the test sessions