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. 2010 Nov;88(5):973–979. doi: 10.1189/jlb.0510262

Figure 4. RAGE plays a major role in modulating phagocytosis of apoptotic neutrophils by macrophages.

Figure 4.

(A) Peritoneal macrophages from RAGE+/+ and RAGE−/− mice were pretreated with BSA or HMGB1 protein (1 μg/ml) for 1 h followed by incubation with apoptotic neutrophils for 90 min and the phagocytic index then determined. Data shown are representative of 2 independent experiments; ***P < 0.001; *P < 0.05. (B) RAGE+/+ and RAGE−/− macrophages were incubated with apoptotic neutrophils for 15 min and then washed. Western blotting was performed to determine the levels of phosphorylated and total Erk. A representative experiment is shown. A second independent experiment provided similar results.

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