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. 2010 Nov;88(5):863–875. doi: 10.1189/jlb.0510253

Figure 8. Ectopic expression of TRPC1 in Fyn null MCs restores calcium responses, degranulation, and cortical F-actin depolymerization.

Figure 8.

(A) Fyn null MCs stably transduced with TRPC1 express normal levels of TRPC1. One representative of 3 experiments is shown. (B) Fyn null MCs transduced with TRPC1 show enhanced calcium responses, which were measured as described in Materials and Methods. The arrow indicates the time of Ag addition. Data are the mean ± se of all cells analyzed from 3 independent experiments. (C) Degranulation is enhanced by expression of TRPC1 in Fyn null MCs. Data are mean ± se from 3 individual experiments. Statistical significance relative to Fyn null MCs was **P < 0.01. (D) Cortical F-actin depolymerization is restored by expression of TRPC1 in Fyn null MCs. The arrow indicates the time of Ag addition. Mean response (±se) is shown (16–24 cells were monitored in total).