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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2011 Feb;70(2):157–165. doi: 10.1097/NEN.0b013e31820937e4

Figure 2.

Figure 2

Ultrastructural analysis of myelination in Fgf2 null and wt mice. (A–F) Electron micrographs of corpus callosum (CC) in Fgf2 wild type (wt) (A–C) and Fgf2 null (D–F) mice illustrate normal myelination in non-treated (26 weeks) controls (A, D), demyelination after 12 weeks of cuprizone (cup) (B, E), and remyelination after 12 weeks of cup and 6 weeks on normal chow (C, F). (G) The percent of myelinated axons quantified in caudal region of the CC. Fgf2 null mice have a higher proportion of myelinated axons at 12 weeks of cup and during the 6-week recovery period compared to Fgf2 wt mice (p < 0.05 between genotypes across all time points). *p < 0.05 for comparisons of genotypes at each time point.