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. 2008 Aug;49(8):1816–1828. doi: 10.1194/jlr.M800180-JLR200

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Copyright © 2008, American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 3. — Organ weights, cholesterol concentrations, and cholesterol synthesis rates in control mice and in animals lacking GM2/GD2 synthase, GM3 synthase, or both GM2/GD2 and GM3 synthase. Male Galgt1^+/+/Siat9^+/+ (n = 11), Galgt1^−/−/Siat9^+/+ (n = 6), Galgt1^+/+/Siat9^−/− (n = 10), and Galgt1^−/−/Siat9^−/− (n = 6) mice were euthanized at 49 days of age and whole-organ weights (A), tissue cholesterol concentrations (B), and rates of cholesterol synthesis (C) were measured. Cholesterol concentrations are expressed as milligrams of cholesterol per gram wet weight of tissue, and the synthesis rates are expressed as nanomoles of ³H₂O incorporated into sterols per hour per gram of tissue. The asterisk (*) identifies those values in these three groups of mice that were significantly different (P < 0.05) from the respective values in the control Galgt1^+/+/Siat9^+/+ animals. Each column represents the mean ± SEM. nm, not measured.