Fig. 8.

Organ weights, cholesterol concentrations, and cholesterol synthesis rates in mice lacking NPC1 function in the presence and absence of GM3 synthase activity. Groups of npc1^+/+/Siat9^+/+ (n = 11), npc1^−/−/Siat9^+/+ (n = 10), and npc1^−/−/Siat9^−/− (n = 8) mice, both males and females, were maintained on the low-cholesterol diet and studied at 49 days of age. A: Organ weights in these animals. The concentration of cholesterol and the rates of cholesterol synthesis in these organs are illustrated in B and C, respectively. Significant differences (P < 0.05) in the groups are designated by the different letters. Each column represents the mean ± SEM. nm, not measured.