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. Author manuscript; available in PMC: 2011 Apr 7.
Published in final edited form as: Nat Neurosci. 2008 Jun 22;11(7):772–779. doi: 10.1038/nn.2143

Figure 2.

Figure 2

Sanshool inhibits pH-sensitive background potassium channels in sensory neurons. (a) Representative whole-cell voltage-clamp recording from a cultured trigeminal neuron subjected to a voltage ramp (+60 mV to −100 mV, 100 ms; applied every 2 s). Current-voltage relationship before (Bkg) or after application of sanshool (100 μM) or low pH (pH 6.5) (left). Average current recorded at −60 mV in response to sanshool or low pH (right). (b) Dose-response curve of sanshool-evoked inhibition of background potassium conductance in sensory neurons (holding potential = –60 mV) recorded in extracellular Ringer’s solution (IC50 = 69.5 ± 5.3 μM; n = 3–7 cells per point). (c) Summary of sanshool-sensitive currents measured in small- and large-diameter neurons.