Figure 9.

Alterations in regional interneuron distribution alter inhibitory circuitry. A–C, Interneuron accumulation mediated by in utero electroporation of Cxcl12 into the somatosensory cortex increases the frequency but decreases the amplitude of the spontaneous IPSCs recorded from the layer 4 pyramidal neurons on the electroporated side. A, Representative traces from layer 4 pyramidal cell recordings from the four regions in which data were collected (SS, somatosensory cortex; CC, cingulate cortex). The numbering of the white boxes in A″ from Figure 8 corresponds to the number of each trace in A and to indicate the location of the cells that were recorded in B and C. B, Cumulative distribution of sIPSC interevent intervals from pyramidal cells on the electroporated side compared with cells in the corresponding contralateral regions. C, Cumulative distribution of sIPSC amplitudes from pyramidal cells on the electroporated side compared with cells in the corresponding contralateral regions. All errors bars are SEM. EP, Electroporated.