Figure 1.

Hemolysin A family (InterPro: IPR004538) taxonomic coverage of 864 proteins. (A). Taxonomy-tree nodes are placed on the inner circles and radial lines lead to the description for each node. Proteins annotated by taxonomic division are numbered [http://www.ebi.ac.uk/interpro/IEntry?ac=IPR004538]. (B). Multiple sequence alignment of TlyA protein homologs in Mycobacterium. Sequences are colored according to amino acid physicochemical properties; the catalytic tetrad is marked by black asterisks (K69-D154-K182-E238). Similarity values for each amino acid are represented by bars (pink). Organism names correspond to nomenclature found in the tuberculosis database [http://www.tbdb.org/] (CLC sequence viewer alignment representation).